Clinical and Radiological Features of Patients with Coronavirus Disease 2019 (preprint)

Background: Confirmed cases of coronavirus disease 2019 (COVID-19) is still increasing, detailed analysis of confirmed cases may be beneficial for disease control.Methods: To describe the clinical and radiological findings of patients confirmed with COVID-19 infection in Haikou, China.Results: A total of 67 patients confirmed with COVID-19 infection were included in this study. 50 were imported cases. Most infected patients presented with fever and cough. The typical CT findings of lung lesions were bilateral, multifocal lung lesions (52[78%]), with subpleural distribution, and more than two lobes involved (51[78%]). 54 (81%) patients of COVID-19 pneumonia had ground glass opacities. Consolidation was in 30 (45%) patients, crazy paving pattern or interlobular thickening in 17 (25%), adjacent pleura thickening in 23 (34%) patients. Additionally, baseline chest CT did not reveal positive CT findings in 7 patients (23%), but 3 patients presented unilateral ground glass opacities at follow-up. Importantly, the follow-up CT findings were fitted well with the clinical outcomes.Conclusions: Chest CT could be used as an important tool for early diagnosis of COVID-19, monitoring the disease evolution, judging the treatment effectiveness and predicting the clinical outcomes.

Clinical Characteristics of SARS-CoV-2 Infection in Haikou: a study of a family cluster (preprint)

Background The outbreak of sever acute respiratory syndrome coronavirus 2(SARS-CoV-2) has become a great threat to the world. No study has been done on the mild or asymptomatic SARS-CoV-2 in a family cluster.Methods We report the epidemiological, clinical, laboratory, radiological, and clinical outcomes of five patients in a family cluster.Results We enrolled a family of five patients who was confirmed with SARS-CoV-2 infection. One of them worked in Wuhan and returned to Danzhou, Hainan on January 22,2020. The other four family members, who did not travel to Wuhan, became infected with the virus after several days of contact with the family member. Five family members (aged 33–57 years) presented with fever, cough or no symptom onset. Three of them had negative nucleic test on first swab sampling. One of them was not confirmed until the third nucleic acid test. Two of them had radiological ground-glass lung opacities. Two patients presenting with fever had lymphopenia or decreased white blood cells. No one had increased C-reactive protein or lactate dehydrogenase levels. After treatment, they were discharged.Conclusions Person-to-person transmission of SARS-CoV-2 was confirmed in family setting. Concerns should be raised for the asymptomatic persons in a family cluster.

Clinical Characteristics of SARS-CoV-2 Infection in Haikou: a study of a family cluster (preprint)

Background: The outbreak of sever acute respiratory syndrome coronavirus 2(SARS-CoV-2) has become a great threat to the world. No study has been done on the mild or asymptomatic SARS-CoV-2 in a family cluster.Methods: We report the epidemiological, clinical, laboratory, radiological, and clinical outcomes of five patients in a family cluster.Results: We enrolled a family of five patients who was confirmed with SARS-CoV-2 infection. One of them worked in Wuhan and returned to Danzhou, Hainan on January 22,2020. The other four family members, who did not travel to Wuhan, became infected with the virus after several days of contact with the family member. Five family members (aged 33–57years) presented with fever, cough or no symptom onset. Three of them had negative nucleic test on first swab sampling. One of them was not confirmed until the third nucleic acid test. Two of them had radiological ground-glass lung opacities. Two patients presenting with fever had lymphopenia or decreased white blood cells. No one had increased C-reactive protein or lactate dehydrogenase levels. After treatment, they were discharged.Conclusions: Person-to-person transmission of SARS-CoV-2 was confirmed in family setting. Concerns should be raised for the asymptomatic persons in a family cluster.

Clinical and radiological features of patients with 2019 novel coronavirus (SARS-CoV-2) in Haikou, China (preprint)

To describe the clinical and radiological findings of patients confirmed with 2019 novel coronavirus disease (COVID-19) infection in Haikou, China. A total of 67 patients confirmed with COVID-19 infection were included in this study. 50 were imported cases. Most infected patients presented with fever and cough. The typical CT findings of lung lesions were bilateral, multifocal lung lesions (52[78%]), with subpleural distribution, and more than two lobes involved (51[78%]). 54 (81%) patients of COVID-19 pneumonia had ground glass opacities. Consolidation was in 30 (45%) patients, crazy paving pattern or interlobular thickening in 17 (25%), adjacent pleura thickening in 23 (34%) patients. Additionally, baseline chest CT did not reveal positive CT findings in 7 patients (23%), but 3 patients presented unilateral ground glass opacities at follow-up. Importantly, the follow-up CT findings were fitted well with the clinical outcomes.

Early Chest CT Features of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia: Relationship to Diagnosis and Prognosis (preprint)

Objective: To elucidate the consistency between CT findings and real time reverse-transcription–polymerase chain- reaction (RT-PCR) results and investigate the relationship between CT features and clinical prognosis in COVID-19.Methods: The clinical manifestations, laboratory parameters and CT imaging findings were analyzed in thirty-four patients with COVID-19 confirmed by RT-PCR from January 20 to February 4 in Hainan province. CT score was compared between the discharged patients and ICU patients.Results: Fever (85%) and cough (79%) were most commonly seen. 10 (29%) patients demonstrated negative results on their first RT-PCR.22/34(65%) patients showed pure ground glass opacity (GGO). 17/34 (50%) patients had five lobes of lung involvement, while the 23(68%) patients had lower lobes were involved and 24/34 (71%) were subpleural. Lesions of 24 (71%) patients were distributed mainly in the subpleural. During follow-up, the initial CT lesions of ICU patients are distributed in both subpleural and parenchyma (80%) and the lesions are scattered. 60% of ICU patients had five lobes involved, while this was seen in only 25% discharged patients. Lesions of discharged patients are mainly in the subpleural (75%). 62.5% of discharged patients showed pure ground-glass opacity. 80% ICU demonstrated progressive stage on their first CT scan. 75 % discharged patients were at an early stage. CT score of ICU patients were significantly higher than that of the discharged patients.Conclusion: Chest CT plays a crucial role in the early diagnosis of COVID-19, particularly for those patients with negative RT-PCR. The initial features in CT may be associated with prognosis.Authors Hui Juan Chen and Jie Qiu contributed equally to this work.